Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology | Phone: 847-367-4359 | Fax: 847-247-1869
  • 2018 Northeast Veterinary Pathology Conference

    Dr. John Cullen will be speaking on Parenchymal Diseases of the Liver.

  • 2018 Annual Gross Pathology Review Course

    Learn all about gross lesions in domestic, laboratory, and exotic animals.

  • 2018 Descriptive Pathology Course

    Brush ​​up ​​your ​​descriptive ​​​​skills ​​in ​​a ​​supportive environment.

  • Prof. Maja Suter Awarded Coveted Olafson Medal

    This medal has only been awarded 13 times since 1980 to eminent veterinary pathologists. It is highly fitting that Maja Suter is the first female recipient of the Olafson Medal.

  • Student Scholarship Awards

    The Foundation proudly awarded deserving residents and graduate students at the 2017 ACVP Annual Meeting.

  • 2017 Southcentral Division Meeting

    The meeting was held at Texas A&M Galveston Campus in October, 2017. Annual dinner at Landry's!

  • 5th International Seminar on Veterinary Pathology and Ichthyopathology

    It was held at the Universidad National de Colombia in Bogota, Colombia in August, 2017.

  • IV Chilean Meeting on Veterinary Histopathology

    It was organized by Dr. Carlos Gonzalez from Andres Bello University, and sponsored by the Latin Comparative Pathology Group (the Latin-American Division of the Foundation).

CE Portal

Course ID: 166797
Title: Pathology of Zoo Animals

Length: 03:00:00
Author: Dr. Bruce Rideout, DVM, DACVP, Ph.D
Description: This 3-hour lecture on the pathology of zoo animals covers the common and not-so common diseases of a wide range of reptilian, amphibian, avian, and mammalian zoo species.

Noah's Arkive

The Foundation is proud to make Noah's Arkive, a searchable collection of veterinary pathology images, available online at no cost. Special thanks to the University of Georgia for transferring the database and image collection to the Foundation!

Random Image:

CL Davis Diagnostic Exercises

The main goal of these Diagnostic Exercises is to provide interesting cases, focusing on the gross pathological lesions and associated histopathologic or cytologic findings. This material can be of great use for veterinary students, in-training pathologists, and ACVP diplomates alike.

There will be one contribution per month of the year; anyone may contribute. To do so, please contact Dr. Vinicius Carreira at to identify a convenient date for your submission and to receive templates to be used. Spots will be filled out on a first-come first-served basis.

Exercise Thumbnail Answer
Click here for case history Click here for case synopsis

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New today in Noah from Dr. Donal O'Toole of the Wyoming State Veterinary Laboratory.

Tissue from a yearling steer vaccinated 3-months previously with a BVDV product.

Morphologic diagnosis:

Name the condition: Mucosal disease

Cause: Vaccine strain BVDV 125a

Comment: Tissue from a yearling steer vaccinated three months earlier with a BVDV product.

Illness developed in a single source cohort of 461 short yearling Angus-cross steers starting ~2 weeks after vaccination with a MLV BVD product containing type 2 BVDV (125a strain). Terminal disease affected 21 steers at 18-66 days post-vaccination. Lesions were typical of mucosal disease in the 3 submitted carcasses. An additional 17 animals were persistently infected (PI) and remained asymptomatic until culled. Typing the cytopathic BVDV isolate isolated from this and another PI calf indicated they were genetically identical (>99%) in three genomic regions to vaccine BVDV strain 125a. This supported the submitting veterinarian’s suspicion that this was vaccine-precipitated mucosal disease. A surprise was that enteric lesions from this animal had extensive superimposed mycotic infection. BVDV antigen was present in intestinal tissue and brain.

Miller MM et al. Vaccine-associated mucosal disease case study: demonstrating the importance of subsequent herd PI testing. Bovine Practitioner 47: 84-93, 2013.
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Orf virus in human, confirmation in case report from Chile,

C. Flores Olivares; A. Peralta; E. González; A. Verna; A. Peralta; C. Madariaga; A. Odeón; G. Cantón. “Orf virus in human, confrmation in case report from Chile” Rev. chil. Infectol. 2017, (34): 613-5
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New today in Noah from the collection of Dr. Helen Acland.

Tissue from a kitten.

Name the condition: Autosomal recessive polycystic kidney disease.

Comment: Two factors allow a diagnosis of autosomal recessive disease in this cat - the fact that it is a kitten, and the massive size of the kidneys. Animals with ARPKD tend to die within days or weeks of birth. Animals with autosomal dominant disease do not tend to die in infancy, and although there are numerous cysts in their kidneys, undergo a more prolonged course, with marked interstitial fibrosis.

ARPKD is the result of a genetic mutation of the PKHD1 gene which encodes fibrocystin, a component of the primary cilium found in tubular epithelium. Persian cats are over-represented (although they may suffer from autosomal dominant polycystic kidney disease as well). Up to 40% of Persians may be affected with some form of polycystic kidney disease.
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New today in Noah's from the collection of Dr. Helen Acland of the University of Pennsylvania. So much good stuff!

Tissue from a horse.

Morphologic diagnosis: Multiple gastric granulomas

Cause: Draschia megastoma

Comment: The label on this kodachrome said "gastric habronemiasis" because when this image was taken (guess when?) this nematode was still called Habronema megastoma.

Larva of this spirurid nematode are swallowed and burrow into the glandular mucosa of the stomach (often close to the margo plicatus) to form "brood pouches" (other Habronema species live free on the mucosa), from whence the adult females pass larvated eggs into the feces. Perforation and obstruction may be rare side effects.
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New today in Noah - a new case from Drs. Fabrizio Grandi, Camila Neri Barra and Julliana Esteves.

Tissue from an 8-year-old female Persian cat.

Morphologic diagnosis: Diffuse transmural epitheliotropic T cell lymphoma

This patient had a focal mass thickening the jejunal wall on ultrasound examination as well as diarrhea and progressive weight loss.

The cellular morphology and epitheliotropic behavior presented in the small intestine of a cat is distinctive for T-cell lymphoma (TCL). Neoplastic cells were positive for CD3 and negative for CD79a. CD79a-positive lymphocytes were present only in lymphoid follicles.

Intestinal lymphomas can be further classified as mucosal or transmural based on depth of invasion. Epitheliotropism can occur in both types, and occurs most commonly in the villous epithelium. Mucosal T-cell lymphoma closely matches the WHO entity enteropathy-associated T-cell lymphoma (EATCL) type II. Transmural T-cell lymphomas more often can lead to intestinal obstruction and perforation and closely match the WHO entity EATCL type I. Based on the low mitotic rate and the size of the neoplastic cells, this neoplasm was given a diagnosis of low-grade, intermediate cell. The presence of lymphoid follicles within the smooth muscle tunics and serosa is unusual, and likely represent a response to antigens liberated from the breached mucosa.

WSC link:
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