Charles Louis Davis and Samuel Wesley Thompson DVM Foundation

For the Advancement of Veterinary and Comparative Pathology

info@cldavis.org | Phone: 847-367-4359 | Fax: 847-247-1869
  • 2018 General Pathology Review

    Join us for an intensive 4-day session on concepts in general pathology.

  • Prof. Maja Suter Awarded Coveted Olafson Medal

    This medal has only been awarded 13 times since 1980 to eminent veterinary pathologists. It is highly fitting that Maja Suter is the first female recipient of the Olafson Medal.

  • What's New and What's Still True in the 21st Century

    Dr. John Cullen will provide an overview of the liver of domestic animals in health and disease with an emphasis on dogs and cats.

  • IV Chilean Meeting on Veterinary Histopathology

    It was organized by Dr. Carlos Gonzalez from Andres Bello University, and sponsored by the Latin Comparative Pathology Group (the Latin-American Division of the Foundation).

  • Annual Diagnostic Pathology Symposium: Diagnostic Renal Pathology

    Learn about glomerular pathology, glomerular ultrastructure, and pathology of tubulointerstitial disease.

  • 2017 Southcentral Division Meeting

    The meeting was held at Texas A&M Galveston Campus in October, 2017. Annual dinner at Landry's!

  • 5th International Seminar on Veterinary Pathology and Ichthyopathology

    It was held at the Universidad National de Colombia in Bogota, Colombia in August, 2017.

  • Second Annual Course in Peru

    The Foundation held a 3-day course at the Veterinary School of the Universidad Mayor de San Marcos, in the San Borja District of Lima in August, 2017.

Most Requested Publications

We are currently having problems with our bookstore, and we are sorry for the inconvenience. Please call the Main Office at 847-367-4359 to place all orders, and they will be shipped immediately. This problem should be resolved within the month.

CE Portal

Course ID: 166797
Title: Pathology of Zoo Animals


Length: 03:00:00
Author: Dr. Bruce Rideout, DVM, DACVP, Ph.D
Description: This 3-hour lecture on the pathology of zoo animals covers the common and not-so common diseases of a wide range of reptilian, amphibian, avian, and mammalian zoo species.

Noah's Arkive

The Foundation is proud to make Noah's Arkive, a searchable collection of veterinary pathology images, available online at no cost. Special thanks to the University of Georgia for transferring the database and image collection to the Foundation!

Random Image:

CL Davis Diagnostic Exercises

The main goal of these Diagnostic Exercises is to provide interesting cases, focusing on the gross pathological lesions and associated histopathologic or cytologic findings. This material can be of great use for veterinary students, in-training pathologists, and ACVP diplomates alike.

There will be one contribution per month of the year; anyone may contribute. To do so, please contact Dr. Vinicius Carreira at vinicius.carreira@gmail.com to identify a convenient date for your submission and to receive templates to be used. Spots will be filled out on a first-come first-served basis.

Exercise Thumbnail Answer
Click here for case history Click here for case synopsis

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New today in Noah, from Drs. Donal O'Toole of the Wyoming State Vet Lab and Dr. Barb Kizer of USDA-APHIS.

Tissue from an ox.

Morphologic diagnosis: Locally extensive stomatitis, cheilitis and glossitis. Similar lesions involved the dental pad and sublingual mucosa.

Cause: EHDV infection (confirmed by FADL at Plum Island; serotype not established); other possibilities are BVDV-MD, bluetongue, MCF, and chemical or plant-induced stomatitis.

Comment: EHD is common in Wyoming wildlife, particularly white-tailed deer and pronghorn in the eastern (warmer and relatively wetter) half of state. EHD outbreaks typically occur August into September, with large die-offs some years. We don’t hear of EHD in cattle often, and almost never get samples due to its resemblance to FMD (a federal, not state, responsibility in USA). There was an unusual rash of bovine EHD in Nebraska and the Dakotas in 2012, with extension into Wyoming. As is generally the case, this animal recovered. Recently, non-US EHDV serotypes caused outbreaks of oral and pharyngeal disease in cattle elsewhere, particularly Israel, Morocco and Turkey. The case was investigated by Dr. Kizer as an FMD-suspect.
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The winner of the 2017 Student Scholarship Award from Purdue University is Dr. Andrea Pires dos Santos.

"Dr. Andrea Pires dos Santos is the recipient of the 2017 C.L. Davis Foundation Veterinary Pathology Scholarship Award for the Purdue University College of Veterinary Medicine's Department of Comparative Pathobiology. Dr. Santos earned her DVM, MS, and PhD in Brazil. The Brazilian government awarded Dr. Santos a scholarship to come to Purdue for a year of her PhD study to conduct research in a collaborative program. She worked as a postdoctoral research associate at Purdue for 6 ½ years and spent the past 3 years in the non-thesis MS graduate/residency program in clinical pathology at Purdue. She has been an exemplary resident and has a unique background, which includes a strong clinical pathology expertise combined with fifteen years of research on applied molecular biology techniques, which has resulted in many collaborations and over fifty peer-reviewed publications. Her background aligns with her future line of research, which combines molecular techniques in the study of cancer pathology, and early diagnosis of cancers of animals and humans. Dr. Santos has been hired to fill the position of Assistant Professor of Veterinary Clinical Pathology in the Comparative Pathobiology Department, starting July 1, 2017. The Pathology faculty is confident she will have a very successful career as a veterinary clinical pathologist and researcher. "
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The winner of the 2017 Robert L. Farrell Award for Sustained Excellence in Leadership is Dr. John Cullen of North Carolina State University.

John was an undergraduate student and a veterinary student at the University of Pennsylvania. After veterinary school, he was a small animal intern at Angell Memorial Animal Hospital. Following the internship, he was in private practice for another 3 years in regular and emergency clinic roles. At this point a career in anatomic pathology seemed much more attractive than a career as a practitioner. He was offered a position at UC Davis in a combined
residency/PhD program and was happy to accept. Having to choose between a radiation lab study of bone marrow disorders (too complicated), a primate pathology group studying air pollution or a small lab working on liver pathology, a somewhat arbitrary decision became a life-long career. After 5 truly enjoyable years at Davis he left with board certification, a PhD and an enduring enthusiasm for liver pathology. He then accepted a job offer at North Carolina State University that he thought would be a relatively short-term arrangement. Now 33 years later, it is apparent that not all plans proceed according to expectations. Diseases of the liver remain his focus with interests in diagnostic and research applications.
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The 2017 Award for the Best Diagnostic Exercise goes to Dr. Federico Cifuentes.

Federico Cifuentes Ramos is a Professor of Veterinary Pathology who graduated at the Faculty of Veterinary and Animal Sciences of the University of Chile in 2003. He got an MSc and a PhD degree from the same institution in 2009 and 2015 respectively in the area of comparative pathology. After graduating from vet school he worked as a small animal clinician and from 2007 is dedicated full time to veterinary pathology performing research, teaching and service activities.
He has done internships in the Universidad Autónoma de México (UNAM), North Carolina State University, University of Tennessee, Cornell University and the California Animal Health and Food Safety Laboratory (UC Davis). From 2012 he is an associate and funder of a private veterinary pathology laboratory and from 2016 he is an assistant professor in the Department of Animal Pathology at the Faculty of Veterinary and Animal Sciences in the University of Chile.

You can view his and 84 (and counting) other fantastic Diagnostic Exercises at: www.cldavis.org/diag_exercise.html
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Here's another unused WSC case from 2006-2007, submitted by Drs. Meredith Simon, Theresa Albers, and Charles Clifford.

SIGNALMENT: 8 week old, female, athymic nude mouse (CRL:NU-Foxnu/nu) (Mus musculus)

HISTORY:
Sentinel nude mouse submitted for necropsy with a periocular swelling.

LABORATORY RESULTS: Pasteurella pneumotropica was isolated from the periocular mass. Two fluorogenic Taqman® assays targeting the 16s ribosomal DNA were used to distinguish Jawetz and Heyl biotypes of P. pneumotropica, and the isolate was determined to be of the Heyl biotype.

GROSS PATHOLOGIC FINDINGS: A periocular mass is present by the right eye. The contents are purulent and yellow. The right cervical lymph node is mildly enlarged.

CONTRIBUTOR'S MORPHOLOGIC DIAGNOSES: Eye, Harderian gland: Abscess, well-developed, focal, severe.

CONTRIBUTOR'S COMMENT: Pasteurella pneumotropica has long been thought to be a significant pathogen of laboratory mice, although most early reports described pathologic changes now attributed to other agents, such as Mycoplasma pulmonis and Sendai virus. The name, pneumotropica, is somewhat of a misnomer as the bacterium is usually found in the conjunctiva, nasopharynx and female genital tract (1). It can occasionally be found in the lungs of pneumonic immunodeficient mice, usually accompanied by recognized primary pathogens of immunodeficient mice (2).

As P. pneumotropica is widely viewed as an opportunistic, if not primary, pathogen (3), a study was undertaken to evaluate in natural infections: 1) the prevalence of P. pneumotropica in laboratory mice; 2) the pathogenic potential of P. pneumotropica in genetically modified (GM) mice; and 3) to compare the pathogenicity of the Jawetz and Heyl biotypes (1).

Of 25,973 mice screened at a Laboratory Animal Diagnostic Services necropsy laboratory (4), P. pneumotropica was isolated from 4,432 (17.1%), P. multocida from 2 (0.0%) and other Pasteurella spp. were isolated from 53 (0.2%). Gross lesions resembling abscesses were noted in 259 (1%) of the 25,973 mice monitored. The lesions were categorized by location as muzzle (45.5%), skin (17.4%), eye (25%) or internal organ (12.1%). Of those mice with gross lesions, P. pneumotropica was isolated from the lesion in 53(20.5%). Of the 53 lesions, 68.0% were eye lesions which were located primarily in the retrobulbar Harderian gland (Figure). An additional 9.0% were muzzle abscesses and 11.5% each were lesions noted in the skin and internal organs.
Of the 53 mice with lesions from which P. pneumotropica was isolated, 87% were immunodeficient sentinels and 13% were immunocompetent mice, either sentinels (5.5%) or GM mice thought to be immunocompetent (7.5%).

Two fluorogenic Taqman® assays targeting the 16s ribosomal DNA were used to distinguish Jawetz and Heyl biotypes of P. pneumotropica from all isolates that resembled Pasteurellaceae (2). 118 random isolates identified biochemically as P. pneumotropica were evaluated with this assay, including 6 isolates from mice with lesions (4 eye abscesses, 1 urogenital lesion and 1 muzzle lesion) and 112 isolates from routine nasal aspirates from mice without lesions (4). Of the 118 isolates evaluated by PCR, 55.9% were Heyl, 37.3% were Jawetz, and 6.8% were neither the Heyl or Jawetz biotype. Interestingly, all six isolates from lesions were of the Heyl biotype , suggesting that the Heyl biotype is more pathogenic than the others.

Essentially all of the Pasteurella spp. isolated from genetically modified mice are P. pneumotropica. Although P. pneumotropica (identified by biochemical characteristics) is common in laboratory mice, it rarely causes lesions, except in immunodeficient mice, in which the most common lesion is an abscessed retrobulbar Harderian gland. As the immunodeficient sentinels are athymic nude mice, the lack of cilia (hairlessness) may be more important in the development of ocular lesions than immunodeficiency.

REFERENCES (please submit two complete copies of each reference and ensure these are cited in the text of your "contributor's comment" section above, using a numbering format. Use the reference style instructions provided separately):

1. Kodjo A, Villard L, Veillet F, Escande F, Borges E, Maurin F, Bonnod J, Richard Y: Identification by 16S rDNA fragment amplification and determination of genetic diversity by random amplified polymorphic DNA analysis of Pasteurella pneumotropica isolated from laboratory rodents. Lab Anim Sci 49:49-53, 1999
2. Macy JD, Weir EC, Compton SR, Shlomchik MJ, Brownstein DG: Dual infection with Pneumocystis carinii and Pasteurella pneumotropica in B cell-deficient mice: diagnosis and therapy. Lab Anim Sci 50:49-55, 2000.
3. Baker, DG: Natural Pathogens of Laboratory Animals: Their Effects on Research Pasteurella pneumotropica. Pasteurella pneumotropica 49-50 ASM Press, Washington, DC, 2003
4. Fister RD, Pritchett KR, Clifford CB: Characterization of Pasteurella spp. in populations of genetically modified mice: Prevalence, lesions and biotype. ASM Pasteurellaceae, 2005.
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